Inflammation. Disc Degeneration. There is a relationship.
Inflammation is the body’s response to damaging
stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it tries to repair itself
before the harm was achieved. Chiropractic Solutions is always amazed at what the body can do!
Chiropractic Solutions sees its San Jose chiropractic care as a partner of
the body’s system in healing particularly
when there is spine pain. Chiropractic care uses
many tools like spinal manipulation, exercise, and nutrition to take care of
the body. Melatonin is one nutritional tool that is proving value
by interrupting the inflammatory process
related disc herniation that results
in back pain, neck pain and other spine related pain.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are linked to intervertebral disc degeneration. (1) IL-1 β in fact promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body regulates itself down to its cellular level
via autophagy, the natural process during which the body’s
cells clear out damaged (ie, by inflammation) or unneeded parts. In
a new study, melatonin increased autophagy
and reduced the degradation of the disc’s
extracellular matrix (technically marked by a decline
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The final conclusion was that melatonin prevents
intervertebral disc degeneration by stimulating autophagy. (3)
Wow. Chiropractic Solutions is encouraged by this research to see just
how well melatonin can perform for San Jose back pain linked
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is such a common condition
seen at Chiropractic Solutions making positive news like this quite rousing. A new
study stated that melatonin could modulate
the extracellular matrix of the disc remodeling process initiated
by IL-1 β. Further, melatonin reduced the
inflammatory cell collection and reduced the release of connected
inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding
that melatonin interrupted the IL-1B feedback loop, researchers
postulated that melatonin may support
the restoration process of intervertebral discs after damage has already been done. (1) Chiropractic Solutions will keep
following the new research regarding the role inflammation plays
in San Jose disc degeneration and melatonin’s role in tackling
INFLAMMATION AND MELATONIN
The significance of melatonin in helping
to slow or stop painful conditions due to inflammation is rising.
The description of melatonin as a multitasking molecule affecting
mood, immunity, and energy among other mechanisms is quite apropos.
It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by blocking the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland secretes melatonin naturally. Melatonin influences
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) processes. (1) Melatonin’s specific influence on
inflammation and disc degeneration is most attention-getting
to Chiropractic Solutions and our San Jose back pain patients.
CONTACT Chiropractic Solutions
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she illustrates how The Cox® Technic
System of Spinal Pain Management addresses disc
degeneration for relief of chronic low back pain in her patient.
Schedule your San Jose chiropractic appointment with
Chiropractic Solutions now. We can discuss how inflammation affects your
back pain and how melatonin may help with the related disc